If you are a Mayo Clinic patient, this could Seek urgent medical advice if you have difficulty breathing, your throat swells, or have any other signs of an allergic reaction. Recognize the signs and symptoms of benzonatate overdose, which may include restlessness, tremors, convulsions, coma, and cardiac arrest. Is It Possible to Get RSV More Than Once? Always discuss possible side effects with a healthcare provider who knows your medical history. 2. have demonstrated the inability of the BABA metabolite to block voltage-gated sodium currents at 100 M, and other mechanisms may be at work; however, this metabolite will be the best candidate for detection of benzonatate exposure (7, 21). Stop taking benzonatate and get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. (, Bhole, M.V., Manson, A.L., Seneviratne, S.L., Misbah, S.A. (, Cohen, V., Jellinek, S.P., Stansfield, L., Truong, H., Baseluos, C., Marshall, J.P. (, Cohan, J.A., Manning, T.J., Lukash, L., Long, C., Ziminski, K.R., Conradi, S.E. Its effects last for 3 to 8 hours. Benzonatate is a cough suppressant available by prescription as a generic medication or under the brand Tessalon. Sandra C. Bishop-Freeman, Erin M. Shonsey, Laura W. Friederich, Michael C. Beuhler, Ruth E. Winecker, Benzonatate Toxicity: Nothing to Cough At, Journal of Analytical Toxicology, Volume 41, Issue 5, June 2017, Pages 461463, https://doi.org/10.1093/jat/bkx021. Benzonatate is a polyglycol derivative structurally related to procaine and tetracaine. Put the medication in a sealable bag, empty can with a tight lid, or other container to prevent it from breaking out of a garbage bag. no blood pressure or pulse restlessness shakiness in the legs, arms, hands, or feet stopping of the heart trembling or shaking of the hands or feet unconsciousness Other side effects of Benzonatate Some side effects of benzonatate may occur that usually do not need medical attention. : 1056005. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Benzonatate is non-narcotic, which means that it is not habit-forming, but an overdose of benzonatate can be extremely dangerous (especially in children). Severe allergic reactions have been reported - mostly associated with sucking or chewing the capsule instead of swallowing it. Dont worry about airport X-ray machines. Can children take benzonatate (Tessalon)? In several of the published over-ingestion cases, as well as those observed in our office, only a small handful of pills was enough to cause seizures, a cardiac event and death. STORAGE: Store at room temperature away from light and moisture. If you take too much: You could have dangerous levels of the drug in your body. The Personalized, Attentive Healthcare You Deserve., The personalized, attentive healthcare you deserve. The safety and effectiveness of benzonatate in children below the age of 10 years have not been established. Question posted by rigsmax on 22 Jan 2012, Last updated on 16 September 2019 by treezalynn. health information, we will treat all of that information as protected health This medication is sometimes used in dogs for chronic cough. Winter, M.L., Spiller, H.A., Griffith, J.R. (, Oxford University Press is a department of the University of Oxford. Individuals who experience overdose of benzonatate may exhibit restlessness, tremors, convulsions, coma, and cardiac arrest. Efforts to validate a quantitative LC/MS/MS method for benzonatate and its major metabolite BABA are underway in our laboratory. Posted on February 4, 2011 by Albert Fuchs. Serious side effects of benzonatate include choking feeling, chest pain or numbness, feeling like you might pass out, confusion, or hallucinations. Some of these side effects may result from chewing or sucking on a capsule. Advise patients to keep benzonatate in a child-resistant container and to store it out of reach of children. Benzonatate information for Healthcare Professionals. Can celebrex expire/go bad? ongoing numbness or tingling in your mouth, throat, or face; numbness in your chest; a choking feeling; chills; or burning in your eyes. Popular cough relief medicine benzonatate for children 10 and older. Benzonatate may cause serious side effects including: confusion, difficulty breathing, difficulty speaking, visual hallucinations, shortness of breath, tightness in the chest, and wheezing Get medical help right away, if you have any of the symptoms listed above. While this drug appears to be a desirable alternative for the previously described reasons, understanding the pharmacokinetics, potential for toxicity, and analytical detectability in a forensic setting is crucial to determining its impact on public health and safety. Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. totallyforgiven 22 Jan 2012. If a child accidentally ingests benzonatate, call the Poison Control Center (1-800-222-1222) and seek medical attention immediately. (, Evans, M.S., Maglinger, G.B., Fletcher, A.M., Johnson, S.R. Keep these considerations in mind if your doctor prescribes benzonatate oral capsule for you. Copyright 1996-2023 Drugs.com. Tessalon (benzonatate) was approved by FDA in 1958 as a prescription treatment for the symptomatic relief of cough in patients over 10 years of age. Advertising revenue supports our not-for-profit mission. Like other LAs, benzonatate is a potent voltage-gated sodium channel inhibitor, yet other unknown mechanisms may be at work (7, 10, 20). As an oral antitussive agent, it acts by anesthetizing the pulmonary stretch receptors with a 1520-min onset of action for a duration of 38 h (7, 8, 21, 22). Tessalon [Package Insert]. If the patient chews or sucks the liquid-filled capsules or "softgels", the drug can cause laryngospasm, bronchospasm and circulatory collapse. information highlighted below and resubmit the form. The Medical Letter authors conclude when a cough suppressant is truly necessary, dextromethorphan or even codeine might be a safer choice. When codeine compares favorably in safety to another medicine, it might be time to reconsider why we ever use it. Benzonatate is sold under the brand-name Tessalon and is also sold in generic preparations. Can benzonatate be used for a sore throat. Benzonatate. A warning has been put out by the U.S. Food and Drug Administration for the prescription drug benzonatate. An overdose of benzonatate can be fatal, especially to a child. A study done by the FDA. Still looking for answers? Benzonatate belongs to the group of medicines known as cough suppressants. generic drugs) are not considered. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. We comply with the HONcode standard for trustworthy health information. Blood data is inconclusive or unavailable in the majority of death cases (6, 10), however fatalities have been reported with blood concentrations of 5 and 35 mg/L (9, 22). These drugs are often used to treat similar conditions. Purchased benzonatate 2/27/16. Even more challenging is the rapid metabolism of the series of n-ethoxy parent compounds without a suitable pure standard available for quantitation of each specific molecular weight. Copyright 2023 IBM Watson Health. You and your doctor should monitor certain health issues. Do not suck, chew, crush, cut, or break open as this can cause overdosage. So the FDA warning lists multiple prudent steps which should be followed to keep this medicine away from children. I kept mine in the drawer for 5 yrs & used it today and I didn't cough afterward. You may report side effects to FDA at 1-800-FDA-1088. Dr. Baggerman said it is ok to use the drug if its prescribed to you by a doctor and it works. Dosage of drugs is not considered in the study. Advise patients to swallow benzonatate capsules whole and to not break, chew, dissolve, or crush the capsules. Use a cool mist humidifier or a vaporizer to increase air moisture in your home. CERT1_4-03. Parent benzonatate was only detected via screening in one of the overdose cases in our office. Benzonatate relieves cough by acting directly on the lungs and the breathing passages. Is it still safe to take? Coughing can be very disruptive to work and to sleep, and patients can be desperate for relief. Thimann, D.A., Huang, C.J., Goto, C.S., Feng, S.Y. Evans et al. Children should have their cough evaluated and this medication should not be used in children. Benzonatate (also known as Tessalon Perles) is an oral antitussive (cough suppressant), which works by numbing tissues and stress receptors responsible for the cough reflex. Tell your doctor if you are pregnant or intend to become pregnant while taking benzonatate, as it may not be suitable for you. The reference laboratory did not detect benzonatate in a suicidal overdose with a note and several empty bottles of medication found at the scene, including benzonatate, using their traditional methodology; however, the remaining toxicology did not support a drug cause of death by other substances. http://www.fda.gov/drugs/drugsafety/ucm236651.htm (accessed Aug 12, 2016). Taking it again could be fatal (cause death). Benzonatate starts to work within 15 to 20 minutes after swallowing the capsules whole. Dont put this medication in your cars glove compartment or leave it in the car. The effects last for 3 to 8 hours. Image reprinted with permission from Medscape.com, 2010. Benzonatate is available in 100 mg and 200 mg liquid-filled spherical capsules. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. Can be taken up to three times daily. Call 911 if your symptoms feel life-threatening or if you think youre having a medical emergency. Copyright 2022 Scripps Media, Inc. All rights reserved. This means you may need to take it with other medications. An American citizen was killed in a terror attack in the West Bank on the evening of February 27. Other drugs may interact with benzonatate, including prescription and over-the-counter medicines, vitamins, and herbal products. Benzonatate is a non-narcotic cough medicine. To find out how benzonatate oral capsule might interact with something else youre taking, talk to your doctor or pharmacist. (Links to The Medical Letter review and the FDA warning are below.). A class of drugs is a group of medications that work in a similar way. Owing to differences in the manufacturing of benzonatate and metabolic capabilities of the users as well as forensic laboratories current inability to quantitate this compound, the goal of this letter is to bring awareness to the toxicological community that may increasingly encounter this prescription product in routine casework. Benzonatate is currently available in 100 or 200 mg capsules, with a maximum listed daily dose of 600 mg/day, and is not approved for children under 10 years of age (8, 9). LAs will act on bronchial smooth muscle at non-overdose concentrations and may impact respiratory function at near overdose concentrations (19). Be sure to tell your doctor about all medications, vitamins, or herbs youre taking. Symptoms include stuffy nose, coughing, sore throat, fever. Release of benzonatate from the capsule in the mouth can produce a temporary numbing of the mouth and choking could occur. 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